signet-ring cell


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signet-ring cell

[′sig·nət ‚riŋ ′sel]
(histology)
A cell with a large fat- or carbohydrate-filled vacuole that pushes the nucleus against the cell membrane.
References in periodicals archive ?
Clinicopathologic features and utility of immunohistochemical markers in signet-ring cell adenocarcinoma of the bladder.
Metastatic signet-ring cell cancer of the bladder responding to chemotherapy with capecitabine: Case report and review of literature.
If signet-ring cell cancer is found on biopsy of the tonsil or neck, one should evaluate the entire gastrointestinal tract to look for a primary tumor.
Signet-ring cell carcinoma of the rectum with tonsillar metastasis: A case report.
The signet-ring cell type is an independent predictor of death," Dr.
The tumor in our case showed signet-ring cell morphology, lacked mucin and expression of pancytokeratin, and was positive for melanocytic markers by immunohistochemistry; therefore, the tumor was diagnosed as signetring cell melanoma.
To our knowledge, the case we describe is the first gastroesophageal junction signet-ring cell melanoma, and the second case of signet-ring cell melanoma documented in the digestive tract.
Adeno- or signet-ring cell carcinomas identified in the bladder are rare entities and may represent metastases from other primary sites, usually from the gastrointestinal tract.
Case reports of signet-ring cell carcinoma originating from different primary sites but also adenocarcinomas of the bladder indicate similar experiences in as much that responses, if encountered, appear to follow 5-FU-based regimens.
By convention, signet-ring cell carcinomas, small cell carcinomas, and undifferentiated carcinomas are high grade (see note C).
Signet-ring cells associated with pseudomembranous colitis.
In yet other studies, mucinous carcinoma has been linked to adverse outcome only when mucinous and signet-ring cell carcinomas have been grouped together and compared with typical adenocarcinoma.