It overviews gastrointestinal physiology and how it governs oral drug delivery, and discusses the use of polymers in conventional oral dosage forms, including tablets and pellets; more advanced use in extended or sustained release drug delivery, including inert and swellable matrices and osmotic systems; and specific applications, such as those used for gastroretention and associated drug delivery systems, site-specific delivery
to the small intestine and colon, mucoadhesion, and those suitable for micro- and nano-particles for protein and gene delivery.
This is widely used in a number of commercial products, including Asacol[R], Ipocol[R], Mesren[R]MR, tablets for site-specific delivery
of the anti-inflammatory drug mesalazine (mesalamine) to the large intestine for the treatment of ulcerative colitis.
Opsona has developed OPN-501, an oral pro-drug for the treatment of inflammatory bowel disease (IBD) including Ulcerative Colitis and Chrohn's disease that allows site-specific delivery
of the active drug to the colon while suppressing absorption in the stomach and small intestine, improving the effectiveness and reducing side effects.