Group E served as experimental group and was given sodium cyclamate 60mg/kg/day through oral gavage tube for two months.
Conclusion: Sodium cyclamate affects the histomorphology of endocrine pancreas by increasing the area of islets of langerhans in treated group.
Keywords: Islets of langerhans, Pancreatic lesions, Sodium cyclamate.
However, in 1977, the Committee on Food Additives at the World Health Organization (WHO), approved the use of sodium cyclamate as a food additive in more than 40 countries (Boop et al.
1970), sodium cyclamate crosses the placental barrier approaching a fetal concentration of this substance equivalent to one quarter of the existent maternal concentration.
Yet it is important to note that most publications on the effects of sodium cyclamate occurred in the 1960s and 1970s, and that this output has reduced afterwards mostly due to prohibition of the use of this substance by the FDA in the United States of America, in 1969 (Egeberg et al.
The livers of ten rats were evaluated, five treated and five controls chosen at random, in which five rats that received from the 10th to 14th days of pregnancy an intraperitoneal daily injection of sodium cyclamate at 60 mg/Kg of body weight during 5 days.
However, the World Health Organization's Joint Expert Committee on food Additives approved the use of sodium cyclamate in 1977, as an alimentary additive in more than 40 countries including Brazil (Boop et al.
sodium cyclamate can cross the placental barrier and approach a fetal concentration one fourth that of maternal one.
The purpose of this research was to assess the effect of sodium cyclamate in kidneys of rats fetuses considering morphometric changes of glomerulus, proximal and distal convoluted tubules, and collecting duct.
The composition of the product appears in different forms: sodium cyclamate, calcium cyclamate and cyclamic acid (Cattanach, 1976).
Despite this, the World Health Organization approved the use of sodium cyclamate in 1977 asa sweetener for foods and beverages in more than 40 countries (Ahmed & Thomas, 1992).