sparteine


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sparteine

[′spärd·ē‚ēn]
(organic chemistry)
C15H26N2 A poisonous, colorless, oily alkaloid; soluble in alcohol and ether, slightly soluble in water; boils at 173°C; used in medicine. Also known as lupinidine.
References in periodicals archive ?
7) In addition to biochemical evidence, the colocalization of sparteine oxidation deficiency and of the CYP2D6 locus at chromosome 22q13.
Proceedings: N-oxidation of sparteine in man and its interindividual differences.
Phenotyping investigations in whites have consistently shown that 5% to 10% of the population are poor metabolizers with high metabolic ratios for probe drugs such as debrisoquin, sparteine, and dextromethorphan; in Asians only 0% to 1% of populations display poor metabolizing behavior.
Pharmaco-genetic covariation of defective N-oxidation of sparteine and 4-hydroxylation of debrisoquine.
Codeine increases pain thresholds to copper vapor laser stimuli in extensive but not poor metabolizers of sparteine.
In previous studies individuals have been classified as poor, extensive, or ultrarapid CYP2D6 metabolizers according to their metabolic activity exerted on specific test drugs such as debrisoquine or sparteine (28-30).
Influence of CYP2D6 genotype and medication on the sparteine metabolic ratio of psychiatric patients.
A missense mutation in exon 6 of the CYP2D6 gene leading to a histidine 324 to proline exchange is associated with the poor metabolizer phenotype of sparteine.
Pharmacokinetics and metabolism of quinidine in extensive and poor metabolizers of sparteine.
Several additional drugs have been identified for use in phenotyping studies, including sparteine and dextromethorphan, and more recently propafenone (Table 3) [16].