sphingomyelin


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Related to sphingomyelin: cerebroside, sphingolipid

sphingomyelin

[¦sfiŋ·gō′mī·ə·lən]
(biochemistry)
A phospholipid consisting of choline, sphingosine, phosphoric acid, and a fatty acid.
References in periodicals archive ?
Noting that sphingomyelin (SM) is more abundant in larger and less dense LDL particles (14), we speculated that SMase might preferentiallydissociate lb-LDL, thus enabling the detection of the remaining LDL (which is sd-LDL) by a general cholesterol assay.
Amniotic Fluid Sphingomyelin Quantification Identifies G1-[alpha] Gene Mutations of Unclear Significance
Additionally, Manjunath and Therien [119] found that the BSP proteins, which bind to sperm plasma membrane phospholipids specifically phosphatidylcholine, phophatidylcholine plasmalogen and sphingomyelin, stimulated cholesterol and phospholipid efflux from the sperm membrane.
01 TP: Total phospholipids, LPC: Lysophosphatidylcholine, SPM: Sphingomyelin, PC: Phosphatidylcholine, PS: Phosphatidylserine, PEA: Phosphatidylethanolamine, IDA: Iron-deficiency anemia Table 2: Indicators of phospholipid structure for erythrocytes membranes in early-age children with moderate degree IDA in conditions of high mountains in time of treatment termination Analyzed groups Statistical TP (mcg) indication [P.
NK, natural killer; uPAR, urokinase-type plasminogen activator receptor; suPAR, soluble urokinase-type plasminogen activator receptor; GPI, glycosylphosphatidylinositol; TNF, tumor necrosis factor; NFAT, nuclear factor of activated T cells; MMF, mycophenolate mofetil; GTP, guanosine-5'- triphosphate; SMPDL, sphingomyelin phosphodiesterase acid-like; ASMase, acid sphingomyelinase.
Lopez-Sanchez, "Diacylglycerol generated during sphingomyelin synthesis is involved in protein kinase C activation and cell proliferation in Madin-Darby canine kidney cells," Biochemical Journal, vol.
2]S also dissolves well in lipids and readily passes through lipid bilayers, even those containing cholesterol and sphingomyelin, both of which decrease membrane diffusion.
INTRODUCTION: Niemann-pick disease is an autosomal recessive disorder affecting 1 in 2,50,000 children [1] and is characterised by lysosomal accumulation of sphingomyelin resulting from an inherited deficiency of sphingomyelinase.
This finding allowed the host group to rationally design the new antitumor drug MinervalA, first known activator of sphingomyelin synthase (SGMS-1 and -2), the protein responsible for maintaining the balance between PE and SM in the membrane by using the former as substrate to synthesize the latter.
Choline is also a precursor of the phospholipid sphingomyelin (SM), which is important in the myelin sheath of neurons, and in the metabolism of molecules that function in intracellular signaling, specifically diacylglycerol and ceramide.
35] summarize possible roles including: cholesterol esterification, possibly by sphingomyelin translocation regulation i.