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LC-MS conditions for sphingolipids, phosphoglycerides, glycerides and sphingomyelins were previously established (Qu et al.
Thus, 12/15-LOX, by changing the membrane organization, may influence the composition of sphingolipids as ceramides and sphingomyelins.
Their finding: the higher the level of plasma sphingomyelins and the lower the level of ceramide--two types of fat found in cells--the slower dementia will progress.

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