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Sphingosine

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sphingosine [′sfiŋ·gə‚sēn]
(biochemistry)
C18H37O2N A moiety of sphingomyelin, cerebrosides, and certain other phosphatides.
Sphingosine 

an unsaturated higher aliphatic amino alcohol, C13H27CH=CHCH(OH)CH(NH2)CH2OH. Sphingosine is soluble in organic solvents and insoluble in water; its melting point is 81.5°–83°C, and its properties are those of a base. Sphingosine occurs in nature as a constituent of sphingolipids. Its biosynthesis in cells is effected from the amino acid serine and palmitic acid with the participation of coenzyme A. Sphingosine exhibits an anticoagulant effect since it inhibits the conversion of prothrom-bin to thrombin. The more than 60 analogues of sphingosine— sphingosine bases—are distinguished by the length of the aliphatic chain, the degree of nonsaturation, the type of branching, and the location of the double bond.
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The plant chemical delivered a double punch, preventing the creation of two enzymes known to trigger an inflammatory response, sphingosine kinase and phospholipase D.
Red wine may help chronics; health matters by Daily Post (Liverpool, England)
They found that resveratrol used a one-two punch to stop inflammation in the mice by preventing the body from creating two different molecules known to trigger inflammation, sphingosine kinase and phospholipase D.
Healthy secret of red wine uncorked by Asian News International
Additionally, ceramide hydrolysis liberates sphingosine, which also has some antimicrobial efficacy.
Highlights of the 4th International Cosmeceuticals Summit, 9-11 March ... by Knaggs, Helen E. / Clinical Dermatology
 
 
 
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