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Splenomegaly
(redirected from splenitis)

    Also found in: Dictionary/thesaurus, Medical, Wikipedia 0.01 sec.
splenomegaly [‚splē·nə′meg·ə·lē]
(medicine)
Enlargement of the spleen.
Splenomegaly 

in medicine, the enlargement of the spleen. Splenomegaly occurs with diseases of the spleen (tumors, cysts, abscesses), with general infections (sepsis, malaria, typhoid fever, typhus), with blood diseases (leukoses, lymphgranulomatos-es), and with liver diseases. The spleen is examined by palpation while the individual is lying on his side; it will not be felt if its size is normal.

Splenomegaly is often the first manifestation of blood disease. In such cases, splenic puncture is performed in order to make an accurate diagnosis. With chronic leukoses, the spleen may occupy most of the abdomen and weigh as much as 8 kg. Splenomegaly is accompanied by disruption of breathing, blood circulation, and the functions of adjacent organs, including the stomach, intestine, and left kidney. Disturbances of splenic blood circulation (thromboses), suppression of hematopoiesis (hypersplenism), and other complications may also occur. The condition is treated by surgically removing the spleen (splenectomy), by irradiating the spleen with gamma rays, and by administering cytostatics and corticosteroids.
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Predominate lesions were a moderate to severe hepatitis with diffuse single-cell necrosis of hepatocytes and a splenitis characterized by necrosis of cells surrounding the sheathed arteries.
Falcon adenovirus in an American Kestrel (Falco sparverius) by Tomaszewski, Elizabeth K.; Phalen, David N. / Journal of Avian Medicine and Surgery
The prairie dogs in this study did not have necrotizing lymphadenitis or splenitis, which may indicate that these rodents were euthanized relatively early in the disease course.
Monkeypox transmission and pathogenesis in prairie dogs by Zaki, Sherif R. / Emerging Infectious Diseases
PATHOLOGIC FINDINGS General autopsy findings were significant for candidal bronchopneumonia and splenitis, hepatic granulomas consistent with chronic transfusion therapy, and bilateral renal glomerulosclerosis.
Methotrexate-related nonnecrotizing multifocal axonopathy detected by ... by Moore, Brian E.; Somers, Nathan P.; Smith, Thomas W. / Archives of Pathology & Laboratory Medicine
 
 
 
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