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chronic disorder of the small intestine caused by impaired absorption of fat and other nutrients. Two forms of the disease exist.

Tropical sprue occurs in central and northern South America, Asia, Africa, and other specific locations. No cause has been identified, but suggested causes include infection, parasitic infestation, vitamin deficiency, and food toxin. Tropical sprue responds to antibiotic and folic acid therapy.

Nontropical sprue, also called celiac disease, is primarily an autoimmune disease of young children and usually begins between the ages of 6 and 18 months, but it also can be triggered in susceptible adults. It is a hereditary congenital disorder caused by a sensitivity to the gliadin fraction of gluten, a cereal protein, but it appears to require an immunological trigger. The presence of gluten in the diet causes the immune system to attack the villi in the small intestineI,
9th letter of the alphabet. This vowel can be pronounced with a short vowel sound, as the ĭ in sit, or with a long vowel sound, like the ī in ride. The Greek correspondent is iota. J is a formal development from I.
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, interfering with the absorption of nutrients.

Nontropical sprue can be fatal, particularly if growth abnormalities are ignored or unrecognized. It is not known if scrupulous adherence to a gluten-free diet in this disease decreases the likelihood of intestinal lymphoma, but the deletion of gluten from the diet and the intake of vitamin, mineral, and hematinic supplements facilitate remission. Steroid treatments are often used if a gluten-free diet is ineffective; if steroid treatment is ineffective the prognosis is not good.

The symptoms of both types of sprue are generally the same: diarrhea with bulky, frothy, foul-smelling stools containing large amounts of fatty acids and soaps, and later weight loss, anemia, and other symptoms related to malabsorption of vitamins. X-ray examination of the small intestine revealing dilation, segmentation, and other typical changes is used in diagnosis.



a chronic disease of man that affects the bone marrow and the mucous membranes of the tongue, stomach, and intestines. Sprue’s etiology is unknown, but it is suspected that a deficiency of the B-complex vitamins plays a special role. The disease is manifested by persistent diarrhea, anemia, progressive emaciation, and damage to the peripheral nervous system. Sprue occurs primarily in countries with hot climates. In the USSR it occurs in Middle Asia and Transcaucasia. Treatment includes the observance of a protein and fat diet rich in the B-complex vitamins and the use of astringents; change of climate is also recommended.


A feed opening or vertical channel through which molten material, such as metal or plastic, is poured in an injection or transfer mold.
A slug of material that solidifies in the channel.
A syndrome characterized by impaired absorption of food, water, and minerals by the small intestine; symptoms are the result of nutritional deficiencies.
References in periodicals archive ?
If you are gating into the split line of opposing cams, you may not need the sprue-pulling function of a sprue puller, but you will still need the cold-well function.
As part of the transaction, Sprue has hired two of Intamacs senior software development engineers to enable it to operate and maintain the software.
In the initial stages of pouring, the sprue quickly fills and floods the runner.
Sprue Aegis designs and sells innovative smoke and carbon monoxide alarms and other safety products, and is one of the sector leaders in Europe.
Celiac sprue is estimated to afflict as many as one in 200 Americans.
Sprue pullers can be made in any number of design variations.
As part of the negotiations, Sprue has also secured improved manufacturing terms from Detector Technologies Ltd, a Jarden company, which supplies Sprue%s own-brand smoke alarms and other associated accessories:
Sprue Aegis, which is based at the University of Warwick Science Park, employs 63 people in the UK and its workforce is expected to rise again during 2011.
Graham Whitworth, chairman and chief executive of Sprue Aegis said: "We have worked with B&Q over a number of years as a niche supplier; we are therefore delighted with B&Q's decision to partner with FireAngel to launch our next generation "Wi-Safe" range and to carry the entire 600 series of smoke alarms.
6 will provide educational programs for people of all ages and knowledge levels on celiac sprue, a mysterious and incurable digestive disease that causes gluten intolerance.
In July's column on sprue bushings we discussed how to reduce the mass of plastic where the sprue, runner, and cold well intersect at the parting line.
29 April 2013 - UK home safety products supplier Sprue Aegis Plc said its independent directors regard Jarden Corp's (NYSE:JAH) planned bid targetting the shares not yet owned in Sprue, which was unveiled earlier today, as undervaluing and could not advise shareholders to accept it.