sprue

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sprue,

chronic disorder of the small intestine caused by impaired absorption of fat and other nutrients. Two forms of the disease exist.

Tropical sprue occurs in central and northern South America, Asia, Africa, and other specific locations. No cause has been identified, but suggested causes include infection, parasitic infestation, vitamin deficiency, and food toxin. Tropical sprue responds to antibiotic and folic acid therapy.

Nontropical sprue, also called celiac disease, is primarily an autoimmune disease of young children and usually begins between the ages of 6 and 18 months, but it also can be triggered in susceptible adults. It is a hereditary congenital disorder caused by a sensitivity to the gliadin fraction of gluten, a cereal protein, but it appears to require an immunological trigger. The presence of gluten in the diet causes the immune system to attack the villi in the small intestineI,
9th letter of the alphabet. This vowel can be pronounced with a short vowel sound, as the ĭ in sit, or with a long vowel sound, like the ī in ride. The Greek correspondent is iota. J is a formal development from I.
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, interfering with the absorption of nutrients.

Nontropical sprue can be fatal, particularly if growth abnormalities are ignored or unrecognized. It is not known if scrupulous adherence to a gluten-free diet in this disease decreases the likelihood of intestinal lymphoma, but the deletion of gluten from the diet and the intake of vitamin, mineral, and hematinic supplements facilitate remission. Steroid treatments are often used if a gluten-free diet is ineffective; if steroid treatment is ineffective the prognosis is not good.

The symptoms of both types of sprue are generally the same: diarrhea with bulky, frothy, foul-smelling stools containing large amounts of fatty acids and soaps, and later weight loss, anemia, and other symptoms related to malabsorption of vitamins. X-ray examination of the small intestine revealing dilation, segmentation, and other typical changes is used in diagnosis.

Sprue

 

a chronic disease of man that affects the bone marrow and the mucous membranes of the tongue, stomach, and intestines. Sprue’s etiology is unknown, but it is suspected that a deficiency of the B-complex vitamins plays a special role. The disease is manifested by persistent diarrhea, anemia, progressive emaciation, and damage to the peripheral nervous system. Sprue occurs primarily in countries with hot climates. In the USSR it occurs in Middle Asia and Transcaucasia. Treatment includes the observance of a protein and fat diet rich in the B-complex vitamins and the use of astringents; change of climate is also recommended.

sprue

[sprü]
(engineering)
A feed opening or vertical channel through which molten material, such as metal or plastic, is poured in an injection or transfer mold.
A slug of material that solidifies in the channel.
(medicine)
A syndrome characterized by impaired absorption of food, water, and minerals by the small intestine; symptoms are the result of nutritional deficiencies.
References in periodicals archive ?
The conundrum was whether to intentionally leave a space or gap between the end of a hot sprue and the parting line of a cold-runner, two-plate mold.
In the first week of the campaign, and albeit from a relatively low sales base, weekly sales through the till of Sprues CO products doubled.
In the initial stages of pouring, the sprue quickly fills and floods the runner.
Sprues can be used not only for filling cavities, but to pick cavity edges clean (without residual flash).
the TC 1517 accommodates sprues and runners that measure up to 15 x 17 inches.
Sprue is pleased to announce details of the acquisition of source code and development rights to software developed by Intamac Systems Limited (Intamac) (the Intamac Software Acquisition).
Use of the radial choke will minimize the additional generation of dross and trapped air found with reverse tapered sprues but will not resolve problems with contamination that already exists in the metal.
Hot sprues can also be used to retrofit molds with existing cold sprue bushings, the manufacturer notes.
A correctly sized and shaped sprue will help accomplish this as well as some other factors in the runner and ingates.
The SS167 is intended to fill the needs of customers who generate long sprues and runners with their larger injection-molding machines yet want the performance advantages of the slow-speed granulator.