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stress axis

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stress axis [′stres ‚ak·səs]


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Chronic over-secretion of stress hormones by the HPA (Hypothalamic-Pituitary-Adrenal) stress axis leads to increased cortisol levels in the brain, affecting neuronal cells.
Because NO and cortisol play a role in the switch on (NO) switch off (cortisol) phases of the neuroendocrine stress axis they may be used as markers for stress and their activation and suppression may be indicative of the adaptive process.
We hypothesized that PM could act on the brain directly to stimulate the stress axis and predispose individuals to these diseases.
 
 
 
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