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substance P |
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substance P [′səb·stəns ′pē] (biochemistry) An undecapeptide widely distributed in the central nervous system and found in highest concentrations in superficial layers of the dorsal horn of the spinal cord, in the trigeminal nerve nucleus, and in the substantia nigra; acts as a neurotransmitter. How to thank TFD for its existence? Tell a friend about us, add a link to this page, add the site to iGoogle, or visit webmaster's page for free fun content. |
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Basbaum, a neuroscientist at the University of California, San Francisco, studied the distribution of substance P and its receptor molecules in the spinal cord. The peripheral neurons that release substance P are thought to send pain signals to the brain and to help regulate the immune response in damaged tissues. Compounds that moderate Substance P not only moderate pain, but also reduce the inflammation that exacerbates many ailments, such as arthritis and asthma. |
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