suicide inhibitor


Also found in: Medical.

suicide inhibitor

[′sü·ə‚sīd in′hib·əd·ər]
(biochemistry)
A compound which resembles the normal substrate for an enzyme, but which interacts with the enzyme to form a covalent bond and thus inactivates the enzyme.
References in periodicals archive ?
The [alpha]-difluormethylornithine ([alpha]-DFMO), which is the ornithine decarboxylase suicide inhibitor, has been extensively used to study the effects of limiting polyamine synthesis in cell culture and in experimental animals (Poso and Pegg, 1982; Pegg, 1986; Grossie et al.
The ODC suicide inhibitor [alpha]-DMFO has been used in studies of the roles of ODC and polyamines at the biochemical and physiological levels (Bitonti et al.