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syngeneic |
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In a syngeneic bone marrow transplant patient (15), the infection presented as a 3-cm solitary pulmonary nodule, and after 6 weeks of antimicrobial treatment, the culture-positive nodule vanished. The sample consisted of young (8- to 10-week-old), syngeneic, female C57BL/6 mice* (n=50). Alternatively, bone marrow can be harvested from donor mice, altered genetic material introduced in vitro, and the transduced bone marrow transplanted into irradiated syngeneic (genetically identical) recipient mice. |
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