systemic circulation


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Related to systemic circulation: Coronary circulation

systemic circulation

[si′stem·ik ‚sər·kyə′lā·shən]
(physiology)
The general circulation, as distinct from the pulmonary circulation.
References in periodicals archive ?
However, while waiting for surgery it is important to balance the lung circulation and the systemic circulation.
The transdermal delivery route obviates this problem: The drug enters systemic circulation directly, so a therapeutic level is achieved in the brain at a dose that spares MAO-A receptors in the intestine, Dr.
Different from the literature, we aimed to evaluate the preoperative hemodynamic parameters and whether or not the right or the left ventricles supporting the systemic circulation as a "dominant ventricle" pose a risk for postoperative arrhythmia.
In cases where the pulmonary vascular resistance increases, blood flows right-to-left across the VSD, producing cyanosis because more venous blood enters systemic circulation.
We believe this helps prevent the body from producing those harmful chemicals that can enter the systemic circulation and contribute to poorer diabetes control," he added.
Both periodontal disease and RA are associated with inflammatory mechanisms, recruiting inflammatory cells from the systemic circulation to local tissue.
Passage of intratracheally instilled ultrefine particles from the lung into the systemic circulation in hamster.
Because bile acid sequestrants are not absorbed into the systemic circulation, they do not represent a direct risk to the embryo or fetus and are considered compatible with pregnancy (all are rated risk factor B) and lactation.
The gel bypasses gastrointestional absorption, hepatic first-pass metabolism, and systemic circulation.
Importantly, intact KP201 was not detected in systemic circulation during a Phase I study, suggesting that minimal additional studies could be justified to determine the impact of KP201 exposure in the body.
PhaseRx Hybrid mRNA Delivery System(TM) PhaseRx's Hybrid mRNA Delivery System is designed to address the challenges of RNA delivery through protection of the mRNA in the systemic circulation, specifically targeting hepatocytes and by mediating endosome escape and mRNA delivery into cytoplasm.
Lexicon is developing telotristat as therapy for carcinoid syndrome, an orphan' disease that occurs when carcinoid tumors spill excess serotonin into the systemic circulation.