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tachyphylaxis

   Also found in: Dictionary/thesaurus, Medical, Wikipedia 0.01 sec.
tachyphylaxis [‚tak·ə·fə′lak·səs]
(immunology)
Rapid desensitization against doses of organ extracts or serum by the previous inoculation of small subtoxic doses of the same preparation.


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For example, see Genentech's patent application in Europe for "the intermittent administration of insulin-like growth factor (IGF) I to avoid tachyphylaxis (rapid loss of drug efficacy with continued use) during the treatment of a chronic disease[.
2] agonists will also block EIA, but tachyphylaxis and safety concerns mitigate against their use as monotherapy.
 
 
 
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