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tandem duplication

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tandem duplication [′tan·dəm ‚dü·plə′kā·shən]
(cell and molecular biology)
The occurrence of two identical sequences, one following the other, in a chromosome segment.
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The CYP superfamily is also an excellent group for studying the evolutionary mechanisms that create gene families; previous studies of" this group have provided clear examples of the molecular processes, such as tandem duplication and gene conversion, that are considered to be most important in gene family evolution (Fernandez-Salguero et al.
Organization and evolution of the Cyp2 gene cluster on mouse ... by Hoffman, Susan M.G. / Environmental Health Perspectives
Given the poor prognosis associated with activating mutations of FLT3 kinase, the FLT3 genotype of patients was analyzed and it was found that 13 patients had a specific mutation of FLT3 called the internal tandem duplication (ITD) mutation.
Ambit Biosciences Presents Data on its Targeted Cancer Therapeutic ... by Business Wire
The most common Flt3 mutation, the so-called internal tandem duplication, is linked to a particularly poor disease prognosis and is expected to be particularly susceptible to Flt3 inhibition.
ARIAD Presents Unique Profile of Novel Multi-Targeted Kinase ... by Business Wire
 
 
 
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