taxol


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taxol

[′tak‚sōl]
(pharmacology)
C47H51NO14 An alkaloid derived from the Pacific yew tree (Taxus brevifolia) that is used in the treatment of ovarian and breast cancer.
References in periodicals archive ?
Posteriormente, el taxol fue producido semisinteticamente a partir de los precursores tales como: baccatina III y 10 diacetil baccatina III aislados de las agujas y otras especies de Taxus spp.
Through stabilizing key structural components within the cell called microtubules, Taxol interferes with the division of cancer cells and, hence, slows tumor growth.
In experiment with bovine brain tubulin, epothilones competitively inhibit the binding of taxol to microtubules (3), (4).
According to the interim results, Paclical is reducing CA-125 to the same level as Taxol.
Taxol, the trade name of a drug currently used for cancer treatment, has now been shown to promote regeneration of injured central nervous system (CNS)-nerve cells.
Dr Wani isolated Taxol from bark of the rare Pacific Yew tree while working at the Research Triangle Institute in North Carolina in 1967.
The court held, inter alia, that the negligence in the continued administration of Taxol by Nurse Byrd was evident.
According to the article, Taxol killed cells in a way that researchers had never seen before--it blocked cells just when they were going to divide, inhibiting the replication of cells.
It is harvested in the wild, mostly by Aboriginal groups, but because of the growing demand from pharmaceutical companies and the large amount of biomass required, producers of Taxol (TM) want more sustainable, controlled methods.
The data being presented today support the lack of cross resistance between satraplatin and the two taxanes that are currently approved for use as chemotherapeutic agents in the treatment of human cancers - TAXOTERE and TAXOL," said Marcel Rozencweig, M.
Taxol was developed through a cooperative research and development agreement (CRADA) between NIH and the Bristol-Meyers Squibb Company (BMS) and by 2001 had become the best-selling cancer drug in history.
has agreed in principle to pay $670 million to settle substantially all antitrust litigation stemming from its efforts to block generic versions of BuSpar and Taxol, two of its best-selling drugs.