telomerase


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telomerase

[tə′läm·ə‚rās]
(biochemistry)
A deoxyribonucleic acid polymerase that elongates telomeres.
References in periodicals archive ?
3] Nonstandard abbreviations: TRAP, telomeric repeat amplification protocol; hTERT, telomerase reverse transcriptase catalytic subunit; RT-PCR, reverse transcription-PCR; dNTP, deoxynucleoside triphosphate; HEX, 4,7,2',4',5',7'; hexachloro-6-carboxyfluorescein; FAM, 6-carboxyfluorescein; TAM, N,N,N', N'-tetramethyl-6-carboxyrhodamine; and Ct, detection cycle.
The researchers aren't sure how stress affects telomere length and telomerase activity, but they speculate that chemicals known as free radicals might impede telomerase function.
Researchers described how they are using telomerase to find cancers early, to distinguish them from benign growths, to judge cancer's lethal potency and to measure its recurrence after treatment.
We have very much appreciated our partnership with HKUST, which dates from 2000 on the discovery of small molecule telomerase activators by screening libraries of natural product extracts," said David L.
In cancer cells, the enzyme telomerase keeps rebuilding the telomeres, so the cell never receives the cue to stop dividing.
TA Sciences welcomes our first customers and the launch of the world's first telomerase activator product," said Noel Thomas Patton, founder of TA Sciences.
Here we present a novel method that measures telomerase activity with an enzymatic luminometric [PP.
Cancer stem cells are capable of indefinite self-renewal, because of high telomerase activity, and can differentiate into all cells found in a particular tumor type.
Recently ABC has been shown to also inhibit human telomerase activity.
Many details we could only guess at before, we can now see unambiguously, and we now have an understanding of where the different components of telomerase interact," said Juli Feigon, a professor of chemistry and biochemistry in the UCLA College and a senior author of the study.
Connections were also noted between telomerase mutations and a hereditary lung disease called idiopathic pulmonary fibrosis.
Telomerase in human cancer cells is 10 to 20 times more active than in normal body cells.