teratogen

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teratogen

[tə′rad·ə·jən]
(medicine)
An agent causing formation of a congenital anomaly or monstrosity.
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With the publication of each of these studies, we are moving toward an era where the question of teratogenicity is no longer just "yes" or "no," but dose dependent.
In another study, several mechanisms of teratogenicity have been postulated but with uncertainty.
In addition, teratogenicity assay is the measure of the teratogenic effect (developmental defects) of a certain drugs to the embryo [8].
Effect of folic acid on vitamin A induced cardiac teratogenicity in albino mice.
At this time, more than 400 patients are enrolled in the registry, which began in 2011 in an effort to build a definitive database on teratogenicity and atypicals in pregnancy.
Teratogenicity in pregnant mice: The study was carried out after approval from Animal Ethics Committee of University College of Pharmacy (UCP), University of the Punjab (PU), Lahore-Pakistan, (Approval No.
An attempt should be made to reduce the dose of VPA below 1 000 mg/day, as the risk of teratogenicity is much higher above this dose.
Preclinical data for lorcaserin did not suggest teratogenicity, but maternal exposure in rats late in gestation resulted in lower pup body weight that persisted into adulthood.
Teratogenicity is the best-known serious adverse effect, and the risk of 'retinoid embryopathy' is as high as for thalidomide; mucocutaneous side-effects include initial worsening of acne, xerosis and cheilitis, retinoid dermatitis, and staphylococcal infections of the skin; ocular complications include dry eyes that can persist indefinitely; and severe depression can occur as a rare and idiosyncratic event requiring prompt attention.
We assumed that clinicians would discuss with patients the teratogenicity of valproate, along with other common side effects--weight gain, pancreatitis, effect on liver function tests, thrombocytopenia, and polycystic ovary syndrome--before initiating the drug.