tetanus (redirected from tetanus and diphtheria toxoids)

tetanus (tĕt`nəs, –ənəs) or lockjaw, acute infectious disease of the central nervous system caused by the toxins of Clostridium tetani. The organism has a widespread distribution and is common in the soil, human and animal feces, and the digestive tracts of animals and humans; however, the toxin is destroyed by intestinal enzymes. Infection with the tetanus bacillus may follow any type of injury, whether incurred indoors or out, including nail puncture wounds, insect bites, splinter injuries, gunshot wounds, burns, lacerations, and fractures. Deep puncture wounds are most dangerous, since the bacillus thrives in an anaerobic environment.

The tetanus toxin, one of the most potent poisons known, acts on the motor nerves and causes muscle spasm at the site of infection and in other areas of the body. The most frequent symptom is stiffness of the jaw (lockjaw) and facial muscles. Difficulty in breathing and severe convulsions may ensue. The mortality rate is very high, especially in the very young and the aged; overall it is about 40%. Treatment with tetanus antitoxin should be started promptly in conjunction with human immune globulin. It is preferable, however, to prevent the disease by active immunization (including booster shots) with tetanus toxoid (see vaccination).

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tetanus

 or lockjaw

Acute bacterial disease caused by Clostridium tetani (see clostridium). Spores of this organism are common, especially in soil; it thrives away from oxygen in deep wounds, especially punctures. Its toxin stimulates nerves, causing muscle rigidity with frequent spasms. This may occur around the site of the wound or, if the toxin reaches spinal motor ganglia via the bloodstream, throughout the body. The jaw muscles are almost always involved (lockjaw). Vaccination every few years is the best protection; an antitoxin prevents or delays symptoms in cases of suspect wounds but has limited value once they develop. Treatment usually includes antibiotics, sedatives, and muscle relaxants. Recovered patients are not immune.

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tetanus

1. an acute infectious disease in which sustained muscular spasm, contraction, and convulsion are caused by the release of exotoxins from the bacterium, Clostridium tetani: infection usually occurs through a contaminated wound

2. Physiol any tense contraction of a muscle, esp when produced by electric shocks

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tetanus [′tet·ən·əs]

(medicine)

An infectious disease of humans and animals caused by the toxin ofClostridium tetaniand characterized by convulsive tonic contractions of voluntary muscles; infection commonly follows dirt contamination of deep wounds or other injured tissue. Also known as lockjaw.