tetrahydrofolic acid


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tetrahydrofolic acid:

see coenzymecoenzyme
, any one of a group of relatively small organic molecules required for the catalytic function of certain enzymes. A coenzyme may either be attached by covalent bonds to a particular enzyme or exist freely in solution, but in either case it participates intimately in
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References in periodicals archive ?
The basic principle of its therapeutic efficacy is related to the inhibition of dihydrofolate reductase, a key enzyme in the folic acid metabolism, which converts dihydrofolicacid to tetrahydrofolic acid.
Other forms present may include pteroylglutamic acid (PGA), 5-formyltetrahydrofolic acid (5-formylTHF), tetrahydrofolic acid (THF), and other reduced forms (10, 11), and possibly 4-[alpha]-hydroxy-5-methylTHF (hmTHF) (12).
Trimethoprim is an analog of a portion of another substrate in the pathway, dihydrofolic acid, and competes with it for the enzyme that catalyzes its conversion to tetrahydrofolic acid.