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(organic chemistry)
C7H8N4O2·H2O Alkaloid from tea leaves; bitter-tasting white crystals slightly soluble in water and alcohol, melts at 272°C; used in medicine.



(1,3-dimethylxanthine), an alkaloid of the group of urines; small quantities are found in tea leaves. In pharmacological activity, theophylline is similar to theobromine, from which it differs in its more pronounced diuretic action. Theophylline dilates the blood vessels of the heart and the bronchial musculature and excites the central nervous system. It is prescribed internally, in powder form, and rectally, as suppositories. It is a constituent of Teofedrin and other compound preparations. It is obtained by chemical synthesis from dimethylurea and ethyl cyanoacetate.

References in periodicals archive ?
We measured plasma theophylline and its metabolites in 132 patients treated with theophylline and found a mean (SD) ratio for 1,3-DMU to theophylline of 0.
Less than 1% of the maternal dose of theophylline is excreted into breast milk.
Theophylline was already known to have anti-inflammatory properties and has been used for many years as an asthma treatment.
The company failed to produce the letter even after the Pollocks and Klicpera filed a discovery motion in 1986, which sought "any letters sent by your company to physicians concerning theophylline toxicity in children.
During discovery, the plaintiffs sent several sets of interrogatories requesting information on Somophylline and theophylline.
The study included 255 children with asthma treated with theophylline.
As with any medicine, beta-2 agonists and theophylline medications for asthma should be administered under the supervision of a physician knowledgeable about their proper use and potential side effects.
Theophylline has somewhat better relaxing qualities so the bronchial tubes expand somewhat better.
SAN FRANCISCO -- Patients with chronic obstructive pulmonary disease do worse when their regimens includes theophylline or ipratropium, according to two poster presentations by Todd A.
Gary Moore was fined pounds 1,300 after Miss McGuire tested positive for caffeine and theophylline, both banned substances, when running unplaced at Epsom on July 20.
SRM 3244 adds values for caffeine, theobromin, theophylline and nutrients including fat, protein, carbohydrate, individual fatty acids and amino acids, vitamins and nutritive elements.
A next step toward decaffeinated plants, says Gallivan, is to engineer the cells to produce theophylline themselves.