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thiouracil |
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thiouracil [′thī·ō′yu̇r·ə‚sil] (pharmacology) C4H4N2OS A bitter-tasting white powder; used as an antithyroid drug that acts by interfering with thyroxine synthesis. How to thank TFD for its existence? Tell a friend about us, add a link to this page, add the site to iGoogle, or visit webmaster's page for free fun content. |
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Similar thyroid hyperplasia has been observed after treatment of fish with goitrogens such as thiourea and thiouracil that inhibit coupling and formation of iodotyrosines in the thyroid. Because PBDEs have the ability to interfere with thyroid hormone (TH) homeostasis, we included a reference group for TH-mediated effects by adding the goitrogen 6-n-propyl thiouracil (PTU) in the drinking water of pregnant females. Pregnant rats fed the antithyroid pharmaceutical propyl thiouracil had both difficulty hearing low and intermediate frequency clicking sounds and loss of motor coordination (Goldey et al. |
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