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thiouracil

   Also found in: Dictionary/thesaurus, Medical, Wikipedia 0.01 sec.
thiouracil [′thī·ō′yu̇r·ə‚sil]
(pharmacology)
C4H4N2OS A bitter-tasting white powder; used as an antithyroid drug that acts by interfering with thyroxine synthesis.


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When relative efficacy was compared with that of propyl thiouracil (PTU), a standard antithyroidic drug, experimental seed extract appeared to be more effective.
Similar thyroid hyperplasia has been observed after treatment of fish with goitrogens such as thiourea and thiouracil that inhibit coupling and formation of iodotyrosines in the thyroid.
Because PBDEs have the ability to interfere with thyroid hormone (TH) homeostasis, we included a reference group for TH-mediated effects by adding the goitrogen 6-n-propyl thiouracil (PTU) in the drinking water of pregnant females.
 
 
 
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