Thrombocytopenia

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Related to thrombocytopenic: thrombocytopenic purpura, thrombocytopenia

thrombocytopenia

[¦thräm·bō‚sīd·ō′pē·nē·ə]
(medicine)
The condition of having an abnormally small number of platelets in the circulating blood.

Thrombocytopenia

 

a decrease in the number of platelets to fewer than 200,000 per mm3 in the peripheral blood. It may result from the redistribution of platelets in the bloodstream or from hemorrhage. Other causes are the intensified loss of platelets associated with thrombocytopenic purpura, splenomegaly, disseminated intravascular thrombosis, and the use of certain drugs. Thrombocytopenia may also result from disturbance of platelet formation in the bone marrow in leukemia or aplastic anemia, and from ionizing radiation. Blood clotting is impaired in thrombocytopenia, resulting in a tendency of the mucous membranes to bleed, as well as in hemorrhaging and the appearance of petechiae in the internal organs. Bleeding usually becomes continuous when the platelet count falls below 20,000–30,000 per mm3 of blood. Therapy involves treatment of the underlying disease, administration of hemostatics, and transfusion of platelets.

References in periodicals archive ?
Peripheral digit ischemic syndrome can be a manifestation of postoperative thrombotic thrombocytopenic purpura.
Thrombotic thrombocytopenic purpura precipitated by acute pancreatitis: a report of seven cases from a regional UK TTP registry.
Idiopathic thrombocytopenic purpura: a practice guideline developed by explicit methods for the American Society of Hematology.
Unusually large plasma factor VIII:von Willebrand factor multimers in chronic relapsing thrombotic thrombocytopenic purpura.
Standardization of terminology, definitions and outcome criteria in immune thrombocytopenic purpura of adults and children: report from an international working group.
Comparison of plasma exchange with plasma infusion in the treatment of thrompotic thrombocytopenic purpura.
Thrombotic thrombocytopenic purpura (TTP) is a rare, life-threatening disease characterized by microvascular platelet deposition and thrombus formation with resulting microangiopathic hemolytic anemia (MAHA), thrombocytopenia is often accompanied by fever, renal failure, and neurological deficits.
Von Willebrand factor-cleaving protease in thrombotic thrombocytopenic purpura and the hemolytic-uremic syndrome.
On the other hand, thrombocytopenic samples with higher than normal IPF are often consistent with platelet destruction disorders like immune thrombocytopenic purpura (ITP), thrombotic thrombocytopenic purpura (TTP), disseminated intravascular coagulation (DIC), the effect of drugs or other causes.