thrombolytic drug


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Related to thrombolytic drug: Anticoagulant drug

thrombolytic drug

(thrŏm'bəlĭt`ĭk) or

clot-dissolving drug,

substance, such as streptokinase or tissue plasminogen activator (tPA), that causes the breakdown of blood clots (see thrombosisthrombosis
, obstruction of an artery or vein by a blood clot (thrombus). Arterial thrombosis is generally more serious because the supply of oxygen and nutrition to an area of the body is halted.
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) that obstruct the flow of blood through the vessels. Its uses include injection during or shortly after a heart attack or strokestroke,
destruction of brain tissue as a result of intracerebral hemorrhage or infarction caused by thrombosis (clotting) or embolus (obstruction in a blood vessel caused by clotted blood or other foreign matter circulating in the bloodstream); formerly called apoplexy.
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 (see infarctioninfarction,
blockage of blood circulation to a localized area or organ of the body resulting in tissue death. Infarctions commonly occur in the spleen, kidney, lungs, brain, and heart.
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) to prevent clots from blocking blood flow to the heart muscle or brain.
References in periodicals archive ?
Streptokinase is not widely used as a thrombolytic drug in the United States.
According to Datamonitor, less than 6% of patients with ischemic stroke receive the thrombolytic drug tPA, the only drug currently approved by the FDA to treat acute ischemic stroke.
Ultrasound devices enable dissolution of blood clots by directing ultrasound energy alone, combining ultrasound with a thrombolytic drug, or by triple therapy of ultrasound, drug and microbubble agent to accelerate the therapeutic effect.
Also, the long time that it takes for infusion of the thrombolytic drug has been associated with the risk of major bleeding.
The market potential for a new specific Urokinase-based thrombolytic drug is in excess of $100 million annually.
a biopharmaceutical company developing innovative therapies for vascular diseases including stroke, today announced the Company has acquired the thrombolytic drug Abbokinase(R).
Alfimeprase, currently in Phase III ALI trials, is the new thrombolytic drug that is in the most advanced clinical stage.
Unlike catheters constructed with side holes, the SpeedLyser(TM) thrombolytic catheter has slits to help evenly distribute the thrombolytic drug to the blockage.
SonoLysis may accelerate the activity of a thrombolytic drug, however, preclinical animal models have shown it is also effective without administering a thrombolytic agent.
Thrombolytic drugs act rapidly to dissolve unwanted blood clots (thrombi) in blood vessels.
Each of the health boards in Wales now offers the use of thrombolytic drugs, used to break up blood clots in the hours after a stroke begins.
Lifesaving thrombolytic drugs are now given to one in five stroke victims in London, the highest rate in the UK, compared to one in ten patients in Birmingham.