microangiopathy

(redirected from thrombotic microangiopathy)
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microangiopathy

[‚mī·krō‚an·jē′äp·ə·thē]
(medicine)
The development of lesions in small blood vessels throughout the body.
References in periodicals archive ?
Buser M, Felizeter-Kessler M, Lenggenhager D, Maeder MT Rapidly progressive pulmonary hypertension in a patient with pulmonary tumor thrombotic microangiopathy.
The cases presented here are the first two cases describing thrombotic microangiopathy following envenomation with tiger snakes (N.
Renal thrombotic microangiopathy caused by anti-VEGF-antibody treatment for metastatic renal-cell carcinoma.
Risk factor analysis for thrombotic microangiopathy after reduced-intensity or myeloablative allogeneic hematopoietic stem cell transplantation.
Thrombotic microangiopathy is characterized by the association of haemolytic anemia, thrombocytopenia and acute renal insufficiency secondary to the obstruction of the renal microcirculation by platelet thrombi(1,2).
The ASH meeting also featured presentations of two-year data highlighting the long-term benefits of chronic Soliris therapy in patients with aHUS,6,7 an ultra-rare, genetic disease characterized by complement-mediated thrombotic microangiopathy (TMA), the formation of blood clots in small vessels throughout the body.
Pulmonary thrombotic microangiopathy is uncommon, reported in only 3% to 26% of autopsied patients with solid tumors (19-22), and is usually only diagnosed postmortem (23).
SEATTLE, March 10, 2014 /PRNewswire/ -- Omeros Corporation (NASDAQ: OMER) today announced positive data using OMS721, the lead human monoclonal antibody in Omeros' mannan-binding lectin-associated serine protease-2 (MASP-2) program, in ex vivo studies of endothelial activation relevant to the pathophysiology of human atypical hemolytic uremic syndrome (aHUS), a form of thrombotic microangiopathy (TMA).
Vascular lesions that are most frequently encountered range from vascular immune deposits by IF but not LM to lupus vasculopathy with massive noninflammatory small arterial and arteriolar intimal deposits, thrombotic microangiopathy or, on rare occasions, necrotizing arteritis.
2] GP-1), and recognition of features of the illness that can serve as diagnostic clues for individual patients but not as classification criteria for the purpose of clinical trials (livedo, thrombocytopenia, cardiac valve disease, renal thrombotic microangiopathy, and some research laboratory-identified antibodies) (Table 1).
Thrombotic microangiopathy with glomerular thrombi and atrophy
Soliris is also approved in the United States and European Union as the first and only treatment for patients with atypical hemolytic uremic syndrome (aHUS), a debilitating, ultra-rare, life-threatening and chronic genetic disorder characterized by complement-mediated thrombotic microangiopathy (blood clots in small vessels).