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Thymidine

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thymidine [′thī·mə‚dēn]
(biochemistry)
C10H14N2O5A nucleoside derived from deoxyribonucleic acid; essential growth factor for certain microorganisms in mediums lacking vitamin B12and folic acid.
Thymidine 

a natural organic compound, a nucleoside consisting of the pyrimidine base thymine and the carbohydrate deoxyri-bose. Thymidine is made up of acicular crystals that are readily soluble in water. With respect to chemical properties, it is a weak base. Thymidine is present in all living cells as a constituent of deoxyribonucleic acid (DNA). Thymidine tagged with radioactive tritium is extensively used in laboratories to study DNA biosynthesis and the repair of DNA after injury.
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However, patients in this study were identified as having failing treatment through viral load testing, suggesting that rates of thymidine analogue resistance could have been much higher if viral load monitoring had not been available.
Dual drug class resistance in two-thirds of those failing ... by Farham, Bridget / CME: Your SA Journal of CPD
69) For TdR, the rate-limiting steps are the initial phosphorylation catalyzed by thymidine kinase-1 (TK1) and the incorporation of thymidine triphosphate (TTP) into DNA, the latter step being the one that determines TdR retention in somatic tumors and probably in brain tumors as well.
The role of PET in the management of brain tumors by Spence, Alexander M.; Mankoff, David A.; Muzi, Mark / Applied Radiology
H]] Thymidine (25Ci/mmol) was purchased from NEN Life Science Products (Boston, MA).
Characterization and biological activity of the main flavonoids from ... by Ninfali, P.; Bacchiocca, M.; Antonelli, A.; Biagiotti, E.; Di Gioacchino, A.M.; Piccoli, G.; Stocchi / Phytomedicine: International Journal of Phytotherapy & Phytopharmacology
 
 
 
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