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thyrotropin |
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thyrotropin (thī'rätrō`pĭn) or thyroid-stimulating hormone (TSH), hormone hormone, secretory substance carried from one gland or organ of the body via the bloodstream to more or less specific tissues, where it exerts some influence upon the metabolism of the target tissue. ..... Click the link for more information. released by the anterior pituitary gland pituitary gland, small oval endocrine gland that lies at the base of the brain . It is sometimes called the master gland of the body because all the other endocrine glands depend on its secretions for stimulation (see endocrine system ). ..... Click the link for more information. that stimulates the thyroid gland thyroid gland, endocrine gland, situated in the neck, that secretes hormones necessary for growth and proper metabolism. It consists of two lobes connected by a narrow segment called the isthmus. The lobes lie on either side of the trachea, the isthmus in front of it. ..... Click the link for more information. to release thyroxine thyroxine (thīrŏk`sēn), substance secreted by the thyroid gland . ..... Click the link for more information. . The release of thyrotropin is triggered by the action of thyrotropin-releasing factor (TRF), a substance found in the hypothalamus of the brain. TRF, once released from the hypothalamus, travels in the bloodstream to the anterior pituitary, where it causes the release of thyrotropin. This latter substance, a glycoprotein (see protein protein, any of the group of highly complex organic compounds found in all living cells and comprising the most abundant class of all biological molecules. Protein comprises approximately 50% of cellular dry weight. ..... Click the link for more information. ), is carried to the thyroid gland by the blood, where it stimulates the uptake of iodine, the conversion of diiodotyrosine to thyroxine, and the secretion of thyroid hormones into the bloodstream. Thyroxine inhibits the further release of thyrotropin by interfering with the action of TRF; thus the levels of thyroid hormones are regulated. If not enough iodine is available in the diet, then not enough thyroxine will be made to shut off the release of thyrotropin. Prolonged stimulation of the thyroid by thyroid-stimulating hormone results in an abnormal enlargement of the gland, known as goiter, a condition which has been largely eradicated by the widespread usage of iodized salt. thyrotropin [thī′rä·trə·pən] (biochemistry) A thyroid-stimulating hormone produced by the adenohypophysis. How to thank TFD for its existence? Tell a friend about us, add a link to this page, add the site to iGoogle, or visit webmaster's page for free fun content. |
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Thyroid disease and high concentration of serum thyrotrophin in a population sample of women: A 4-year follow-up. Included in the Practice Guidelines are an overview of pre-analytic factors, a discussion of the importance of the laboratory-physician interface, and a detailed look at the range of thyroid tests available, including measurement of total and free thyroxine (T4) and triiodothyronine (T3), thyroid stimulating hormone, thyroid autoantibodies (thyroid peroxidase, thyroglobulin, and thyrotrophin receptor antibodies), thyroglobulin, calcitonin, the ret proto-oncogene, and urinary iodide. |
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