There are many mechanism of action of these drugs, as inhibition of microtubule, inhibition of DNA topoisomerase
II or DNA topoisomerase
1 inhibition (Cragg and Newman, 2005).
TEHRAN (FNA)- Problems with a key group of enzymes called topoisomerases
can have profound effects on the genetic machinery behind brain development and potentially lead to autism spectrum disorder (ASD).
Suppressing that many genes across the board-even to a small extent-means a person who is exposed to a topoisomerase
inhibitor during brain development could experience neurological effects equivalent to those seen in a person who gets ASD because of a single faulty gene.
Previous investigations of scientics in the world have releaved that Camptothecin(CPT), 10-Hydroxycamptothecin(10-HCPT), 9-Nitrocamptothecin inhibit topoisomerase
I enzyme in order to have anticancer properties.
A new high-throughput assay, developed recently in the laboratory of Prof Tony Maxwell of the John Innes Centre (and co-founder of Inspiralis), will also provide a huge advance on the standard gel-based screening method for topoisomerase
Savene(R) blocks the activity of the topoisomerase
enzyme and prevents the effect of anthracyclines.
Researchers have been looking at how cancer cells react when given PARP inhibitors alongside a type of chemotherapy called Topoisomerase
1 poisons, which is used to treat bowel cancer, a very common form of the disease.
The researchers looked at how cancer cells reacted when given PARP inhibitors alongside a type of chemotherapy called topoisomerase
The flavonoids fight an enzyme - known as human DNA topoisomerase
II - that is crucial to the spread of cancer cells.
Also molecular property screening methods, including a preferred method, termed end selection, comprised of using an enzyme, such as a topoisomerase
, a restriction endonuclease, &/or a nicking enzyme (such as N.
A new class of cancer drugs -- topoisomerase
inhibitors -- is now in use in the United States for treating certain cancers.
Hoechst 33342 induces apoptosis, inhibits topoisomerase
I, and disrupts TATA box-binding protein/TATA box element binding in BC3H-1 myocytes and HL-60 cells; in contrast, Hoechst 33258 does not have any of these actions[24-27] Our objective was to determine if this apoptotic pathway initiated by Hoechst 33342 was associated with the accumulation of the transcription factor E2F-1.