topoisomerases


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topoisomerases

[¦tä·pō·ī′säm·ə‚rās·əz]
(biochemistry)
Any of a group of enzymes capable of relaxing, unwinding, unpackaging, or changing the degree of supercoiling of deoxyribonucleic acid fiber.
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Data presented included progress made with Xenova's second generation topoisomerase inhibitors and a research update for Xenova's plasminogen activator-1 (PAI-1) inhibition program.
Differential behaviors of Staphylococcus aureus and Escherichia coli type II DNA topoisomerases.
A second novel inhibitor of topoisomerases I and II, XR5944, has shown high potency as a cytotoxic agent in preclinical studies with several different human tumour cell lines and is structurally distinct from both XR5000 and XR11576.
In April this year Xenova's preclinical studies for a novel highly potent topoisomerase I and II inhibitor, XR5944, were the subject of a poster presentation at the meeting of the American Association for Cancer Research in Philadelphia, USA.
Small Molecule Therapeutics will continue to use the whole-cell screening technology to search for other compounds that inhibit the topoisomerases and will seek pharmaceutical partners to develop the compounds into therapies.
XR5000 acts as an inhibitor of both topoisomerase I and II, enzymes which are critically involved in the replication of DNA during the process of cell division and which therefore play a key role in the proliferation of cancer cells.
We achieved significant progress in clinical trials with our topoisomerase I and II inhibitor, XR5000, and our P-gp inhibitor, XR9576.
This study could also explain why some people with mutations in topoisomerases develop autism and other neurodevelopmental disorders.
TEHRAN (FNA)- Problems with a key group of enzymes called topoisomerases can have profound effects on the genetic machinery behind brain development and potentially lead to autism spectrum disorder (ASD).
I read with interest the article entitled: "Evodiamine, a dual catalytic inhibitor of type I and II topoisomerases, exhibits enhanced inhibition against camptothecin resistant cells" (Pan et al.
Topoisomerases, along with gyrases, are enzymes that alter the topology of DNA, performing such functions during cell division as DNA replication, transcription, and recombination; and chromosome condensation and segregation.
Topoisomerases are already targets for several drugs including anti-tumour drugs and antibiotics, such as ciprofloxacin--the anti-anthrax drug.