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topoisomerases

   Also found in: Medical, Wikipedia 0.03 sec.
topoisomerases [¦tä·pō·ī′säm·ə‚rās·əz]
(biochemistry)
Any of a group of enzymes capable of relaxing, unwinding, unpackaging, or changing the degree of supercoiling of deoxyribonucleic acid fiber.


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3) Levofloxacin is the pure S-isomer of ofloxacin (12) and inhibits type II topoisomerases, including the bacterial topoisomerase IV and DNA gyrase.
Cell replication, histones, DNA polymerases, topoisomerases, DNA modification 2B6 1e-48 P08991 Historic H2A variant Urchin 15B4 6e-44 AAC47489 Enhancer of rudimentary Mosquito 15G2 2e-21 CAA28177 Historic H1-beta * Painted urchin 2C7 4e-13 XM_315130 Chief historic H3 * (2)# Mosquito AIV.
The QRDR within topoisomerases contains hotspots for mutations around the active site, which are associated with raised MIC values for fluoroquinolones (10).
 
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