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toxic epidermal necrolysis

   Also found in: Dictionary/thesaurus, Medical, Legal, Acronyms, Wikipedia 0.03 sec.
toxic epidermal necrolysis [¦tak·sik ‚ep·ə‚dər·məl nə′kräl·ə·səs]
(medicine)
Intraepidermal blistering and separation of the outer epidermis, giving the appearance and the management problems of a scald, caused by infection withStaphylococcus aureusstrains producing one of the epidermolytic toxins, usually of phage group II. Also known as scalded skin syndrome.


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In post-marketing experience, rare cases of anaphylaxis and serious skin reactions, including toxic epidermal necrolysis, Stevens-Johnson syndrome and erythema multiforme, have been reported with Tamiflu.
Although our case involved oxaprozin, a sister drug to Bextra, it was only after we settled our lawsuit against Pharmacia and Pfizer, that the company issued a 'Dear Doctor' letter and later changed its package labeling to warn about the risk of SJS and Toxic Epidermal Necrolysis (TEN) associated with Bextra," said Barber.
SJS is also known as Toxic Epidermal Necrolysis Syndrome (TENS).
 
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