transcriptase


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transcriptase

[tran′skrip‚tās]
References in periodicals archive ?
Reverse transcriptase (RT), the major target of antiviral chemotherapy for AIDS/HIV [2] and a key multifunctional enzyme in the life cycle of human immunodeficiency virus type-1 (HIV-1).
Sir Richard Roberts, NEB's CEO, said that WarmStart RTx is an in silico-engineered thermostable reverse transcriptase, designed for speed, sensitivity and inhibitor resistance in reverse transcription loop-mediated isothermal amplification (RT-LAMP), RT-PCR, and other applications where the detection of low-quantities of target RNA from complex sample matrices is crucial.
Citation: "Comparative Analysis of Telomere Length, Telomerase and Reverse Transcriptase Activity in Human Dental Stem Cells;" Jeon, B.
The researchers used X-ray crystallography to describe in atomic detail how the AZT-resistance mutations allow reverse transcriptase to recruit ATP to remove the AZT.
Women given the intervention were 53% less likely than controls to have a mutation that conferred resistance to nonnucleoside reverse transcriptase inhibitors at 6 weeks after delivery.
This effect was not seen in patients who were not exposed to protease inhibitors and was not associated with exposure to non-nucleoside reverse transcriptase inhibitors, although patients were not exposed to this class of drug for as long.
nucleoside analogue reverse transcriptase inhibitors (NRTIs), non-nucleoside reverse transcriptase inhibitors (NNRTIs), RNA polymerase inhibitors, integrase inhibitors.
Reverset is a nucleoside analog reverse transcriptase inhibitor that is being developed as a once-daily oral HIV therapy by Incyte Corporation and Pharmasset, Inc.
Even though other studies showed that elevations in triglyceride and cholesterol and body shape changes were also seen with the other classes of drugs and not just the protease inhibitors, the field had moved to using a non-nucleoside reverse transcriptase inhibitor (NNRTI)-based regimen as part of first-line therapy.
Expression of the catalytic subunit of human telomerase reverse transcriptase independently predicts lower survival in patients who undergo curative resection for hepatic colorectal metastases, reported Julien Domont, M.
Roche announced in April that it would stop malting its nucleoside reverse transcriptase inhibitor Hivid (ddC) and its protease inhibitor Fortovase in 2006.
In December, Bristol-Myers Squibb and Gilead Sciences announced that they will work together to develop a fixed-dose combination of Sustiva, a non-nucleoside reverse transcriptase inhibitor ("non-nuke"), and Truvada, a combination pill containing the nucleoside reverse transcriptase inhibitor ("nuke") Emtriva and the nucleotide reverse transcriptase inhibitor Viread.

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