transcytosis


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transcytosis

[‚tranz‚sī′tō·səs]
(cell and molecular biology)
A form of intracellular vesicular traffic in which endocytosed macromolecules are transferred across the cell and released (via exocytosis) at the opposite plasma membrane domain.
References in periodicals archive ?
These include receptor mediated transcytosis (RMT), increasing permeability and passive diffusion approach.
Receptor-mediated transcytosis can transport peptides and proteins across the BBB.
The pericytes then secrete substances that enhance viral transcytosis across the BBB.
101 It has been shown that tumour necrosis factor alpha (TNFa) significantly upregulated transcytosis of HIV-1 across the trophoblast layer whereas an anti-inflammatory drug (tenidap) significantly reduced transcytosis rates.
The study published in Neuron showed that the Roche Brain Shuttle acts by engaging the natural transferrin receptor (TfR) in a specific mode that triggers a process called receptor-mediated transcytosis to transport molecules into the brain.
TNF-a increases the rate of transcytosis and alters the tight junction permeability (Ma et al.
After DFM are administered to the GIT, they are directly taken up by intestinal epithelial cells via transcytosis.
Park and Simpson (37) reported that BoNT/A, an inhalation poison, works by the active process of binding and transcytosis across airway epithelial cells.
Future work in this field should try to determine whether mucosal antibodies exhibit other functional features, for example, complement fixation, inhibition of epithelial transcytosis, blockade of cell-cell transmission across infectious synapses or antibody-dependent cell cytotoxicity, which may inhibit HIV-1 transmission.
However, transcytosis from epithelial cells occurred within 30 minutes of contact without damaging the cells or cellular junctions (15).
We are currently investigating whether transcytosis of antibody to the RAAG12 positive apical surface, perhaps via Fc receptor-mediated transport, may have contributed to the limited toxicity observed in cynomolgus monkeys.
Preclinical studies indicate that radio-labeled NeuroTrans crosses the blood-brain barrier through transcytosis, or the selective receptor-mediated transport of peptides and large proteins across the endothelial membrane in the BBB.
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