Transferrin


Also found in: Dictionary, Thesaurus, Medical, Acronyms, Wikipedia.
Related to Transferrin: Transferrin saturation, TIBC

transferrin

[′tranz′fer·ən]
(biochemistry)
Any of various beta globulins in blood serum which bind and transport iron to the bone marrow and storage areas.

Transferrin

 

(also siderophilin), any of a group of related complex proteins (glycoproteins) that transport Fe3+ iron ions in organisms. The carbohydrate component of transferrins constitutes approximately 5.5 percent. The molecular weight is approximately 80,000.

Transferrins occur in blood plasma, milk, and egg albumin (conalbumin). In blood plasma, their main functions are the transport of iron (with one molecule of transferrin binding two atoms of trivalent iron) to the reticulocytes, where hemoglobin is synthesized, and the maintenance of the Fe2+/Fe3+ ratio at a certain level. Upon electrophoresis of plasma proteins, transferrin is found in the β-globulin fraction. Transferrins are found in various genetically dependent forms, which have similar physical and chemical properties. A deficiency of transferrin in organisms leads to a number of pathological states caused by disruption of iron metabolism.

REFERENCE

Glikoproteiny, vol. 2. Moscow, 1969. (Translated from English.)
References in periodicals archive ?
For determination of transferrin receptor protein expression, the UltraVision polymer detection kit (Thermo Fisher Scientific GmbH, Dreieich, Germany) was used according to manufacturer's instructions.
Results showed that the amount of artemisinin and transferrin in the tumor increased 10 and 5.
The percentage of saturation of transferrin with iron is determined by the following equation:
Complex checks and balances, exemplified by ferritin and transferrin, supply essential iron while blocking noxious iron excess.
Iron-deficiency anemia: The Kidney Dialysis International Guideline Organization defines iron deficiency warranting iron supplementation in CKD patients as a transferrin saturation of 30% or less and a serum ferritin of 50 ng/mL or less.
Thus, our results showed that IDA in patients with RA is characterized by RBC microcytosis and hypochromia, a reduction in serum iron and ferritin levels, and an increase in serum transferrin and erythropoietin concentrations (Table 2).
Various biochemical parameters are used to diagnose IDA, including ferritin, transferrin saturation (TS), serum iron, and mean corpuscular volume (MCV).
The researchers also identified a common set of genes that influences both transferrin levels and brain structure.
Validity of carbohydrate-deficient transferrin (%CDT), gamma-glutamyltransferase (gamma-GT) and mean corpuscular erythrocyte volume (MCV) as biomarkers for chronic alcohol abuse: a study in patients with alcohol dependence and liver disorders of non-alcoholic and alcoholic origin.
The soluble transferrin receptor level may be a useful assay to delineate causes of anaemia.
Iron deficiency may result from several other less commonly occurring conditions, including a disorder of iron utilization, sideroblastic anemia, selected hemoglobinopathies, anemia related to chronic disorders, chronic inflammation, parasitic infections such as hookworm, and a deficiency of the plasma iron transporting protein, transferrin.
Hucre yuzeyindeki transferrin almaclarinin sayisi hucre icine Fe aliminin temel belirleyicisidir.