trinucleotide repeat expansion

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trinucleotide repeat expansion [‚trī¦nü·klē·ə‚tīd ri′pēt ik‚span·shən]

(genetics)

An increase in the number of copies of a trinucleotide that is normally already present in multiple adjacent copies. For example, the X-linked mental retardation 1 (XLMRI) locus in humans usually contains 6-50 tandem repeats of CCG, but this is expanded to 200-2000 copies in the fragile-X syndrome.

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No references found			An example is fragile X syndrome, which is the result of a trinucleotide repeat expansion in one region of the genome that can result in autistic behavior, intellectual impairment, and seizures. Pharmacogenomics: clinical utility closer by Walsh, Nancy / Clinical Psychiatry News Massimo Pandolfo's Houston laboratory identified the mutation in FRDA, a homozygous GAA trinucleotide repeat expansion on chromosome 9, and established that a protein named frataxin was deficient. The dentate nucleus in Friedreich's ataxia by Koeppen, Arnulf H. / Generations Since many forms of ataxia are caused by trinucleotide repeat expansions we spent a long time developing a method (called the RAPID cloning method) that selectively identifies these genetic changes. SCA5 research update by Day, John / Generations			Trinidad and Tobago Carnival Trinidad and Tobago Emancipation Day Trinidad and Tobago Independence Day Trinidad and Tobago Republic Day Trinidad asphalt Trinidad Lake State Park Trinidad State Beach Trinitarian trinitrobenzene trinitromethane Trinitrotoluene Trinity Trinity Bay Trinity College Trinity County Trinity Park Trinity River National Wildlife Refuge Trinity Sunday Trinity, Holy Trinius, Karl Bernhard trinomial trinomial distribution trinomial nomenclature trinomial surd Trintignant, Jean-Louis trinucleotide repeat expansion Trinux trio trio sonata Triode triode clamp triode clipping circuit triode laser triode transistor Triolet Triolet, Elsa Trionychidae Trionychoidea Triose trioxygen trip trip change trip coil trip hammer trip lamp trip magnet trip rider trip spear tripalmitin tripartite tripartite scheme			trinomial surd Trinomial theorem Trinomial theorem trinomialism trinomialism trinomials trinomials Trinominal Trinominal nomenclature Trinominal nomenclature Trinominal nomenclature Trinonacontane Trinonacontane Trinonacontane Trinoton anserinum Trinoxol Trinoxol Trins Trins Trintignant, Jean-Louis trinuclear Trinuclear Repeat trinucleate trinucleated trinucleotide trinucleotide trinucleotide repeat disease Trinucleotide repeat disorder Trinucleotide repeat disorders Trinucleotide repeat disorders trinucleotide repeat expansion Trinucleotide repeat expansion disease Trinucleotide Repeat Expansion Disorder Trinucleus Trinux trio trio trio Trio Family Trio sonata Trio sonata trio sonatas trio sonatas Triobolar triocephalus Trioctacontane Trioctacontane Trioctacontane Trioctile Trioctyl Trimellitate Trioctyl-Phosphine Oxide triode triode Triode Alternating Current Switch Triode amplifier Triode amplifier triode clamp triode clipping circuit triode laser triode transistor triodes

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