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Trophoblast

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trophoblast [′träf·ə‚blast]
(embryology)
A layer of ectodermal epithelium covering the outer surface of the chorion and chorionic villi of many mammals.

Trophoblast 

the exterior layer of cells in the embryos of mammals. The trophoblast is isolated in the blastocyst stage and makes possible contact between the embryo and the mother’s system by allowing nutrients to pass from the mother to the embryo. The part of the trophoblast located above the embryonic shield is called Rauber’s layer. The trophoblast that is lined internally with mesenchymal cells is called the chorion. The trophoblast plays a role in the implantation of the embryo in the uterine wall and the formation of the placenta.



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If the ovum does implant (after fertilization occurs), then the developing trophoblast will maintain the corpus luteum by producing hCG (human chorionic gonadotropin) until about 8 weeks when the placenta can maintain production of estrogen and progesterone.
The trophoblast theory of cancer (John Beard, 1857-1924) revisited.
SENP2 (SUMO-specific protease 2) is highly expressed in trophoblast cells, which are the stem cells required to form the placenta.
 
 
 
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