tryptophan (redirected from tryptophan oxygenase)

tryptophan (trĭp`təfăn), organic compound, one of the 20 amino acids commonly found in animal proteins. Only the l-stereoisomer appears in mammalian protein. It is one of several essential amino acids needed in the diet; human beings cannot synthesize it from simpler metabolites. Young adults require about 7 mg of this amino acid per day per kg (3 mg per lb) of body weight. Nicotinic acid (niacin), a vitamin of the B complex, can be made from tryptophan in the body, but evidently the rate of transformation is insufficient for the demands of normal growth and maintenance, and hence nicotinic acid must be supplied in the diet. Deficiency of tryptophan in the diet enhances the progress of the vitamin-deficiency disease pellagra, which is treated by restoring nicotinic acid to the diet, usually supplemented with tryptophan. Bacteria in the intestine break tryptophan down to compounds such as skatole and indole, which to a great extent are responsible for the unpleasant odor of feces. Tryptophan contributes to the structure of proteins into which it has been incorporated by the tendency of its side chain to participate in hydrophobic interactions (see isoleucine). The amino acid was isolated from casein (milk protein) in 1901, and its structure was established in 1907.

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tryptophan

One of the essential amino acids. It is a heterocyclic compound that is found in small amounts in most proteins. It plays an important role in the growth and development of infants and in the biosynthesis of serotonin and niacin (thus, deficiency of niacin or tryptophan can cause pellagra). Its occurrence in milk has been suggested as the reason that drinking milk before bedtime helps people sleep. It is used in medicine and nutrition research, in enriched foods, and as a dietary supplement.