tuberculin


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tuberculin

a sterile liquid prepared from cultures of attenuated tubercle bacillus and used in the diagnosis of tuberculosis

Tuberculin

 

a diagnostic agent used to detect an allergic reaction in individuals infected with tubercle bacilli. It was first discovered by R. Koch.

Several types of tuberculin are produced in the USSR, as follows. Liquid tuberculin, or old tuberculin (OT), is prepared by boiling a bouillon culture of tubercle bacilli. Purified protein derivative of tuberculin (PPD) is prepared by adding to a filtrate of bacilli various chemical substances that precipitate proteins, and then purifying the mixture. Liquid purified protein derivative of tuberculin (PPD-L) is prepared by making standard dilutions of purified protein derivative of tuberculin. The tuberculin test detects the presence of tuberculosis; those persons who react positively should then be vaccinated against the disease. The tuberculin test serves as a means of both early diagnosis and of evaluation of the course of tuberculosis. Only the intracutaneous Mantoux test is in wide use in the USSR.

Veterinaries use the tuberculin test to diagnose tuberculosis in animals. The tuberculin is occasionally injected subcutaneously; more commonly, it is injected intracutaneously or into the conjunctival sac. Animals that react positively are considered tuberculotic. A positive reaction is manifested by inflammatory edema after an intracutaneous injection and by purulent conjunctivitis in the eye test.

tuberculin

[tə′bər·kyə·lən]
(immunology)
A preparation containing tuberculoproteins derived from Mycobacterium tuberculosis used in the tuberculin test to determine sensitization to tubercle bacilli.
References in periodicals archive ?
Different diagnostic techniques like tuberculin testing, ZN staining, ELISA, culture isolation and PCR are conventionally used for the detection of Mycobacterium subsp.
Before investigations began, 8 mm would have been classified as a negative result; however, in the context of three other positive tuberculin skin test conversions (>10 mm) among nurses on the same unit, an 8 mm induration in a nurse with a 0 mm TST result upon hire the previous year was considered positive.
The aim of this study is, identified bovine tuberculosis animal based on tuberculin skin test; outcome of a recent intradermal infection of PPD on the sensitivity of the SICTT, in a group of cattle naturally infected with bovine tuberculosis.
Conclusion: Latent tuberculosis infection prevalence was higher based on tuberculin skin test than QuantiFERON- Tuberculosis Gold In-Tube test.
Underreading of the tuberculin skin test reaction, C/resf 1998; 113;1175-1177.
There were no significant relation between tuberculin skin test positivity and presence of BCG scar (P< 0.
Various studies have reported that high smear positivity and cavitatory lesions can more likely transmit infections and thus causing tuberculin skin testing positive in contacts and prevalence of active TB in these suspects is between 1.
The overall frequency of tuberculin skin testing positivity was 41.
Prescription pattern of Tuberculin Skin Test (TST) in a teaching hospital.
The fish were maintained for 4 and 6 weeks before the first and second tuberculin tests respectively and the migration-inhibition assay.
16) Subsequent community-based studies showed that the performance of IGRAs was not superior to that of tuberculin skin tests (TSTs) for diagnosing childhood TB.
On the basis of tuberculin testing, the reported prevalence in Lahore was 6.