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a sterile liquid prepared from cultures of attenuated tubercle bacillus and used in the diagnosis of tuberculosis



a diagnostic agent used to detect an allergic reaction in individuals infected with tubercle bacilli. It was first discovered by R. Koch.

Several types of tuberculin are produced in the USSR, as follows. Liquid tuberculin, or old tuberculin (OT), is prepared by boiling a bouillon culture of tubercle bacilli. Purified protein derivative of tuberculin (PPD) is prepared by adding to a filtrate of bacilli various chemical substances that precipitate proteins, and then purifying the mixture. Liquid purified protein derivative of tuberculin (PPD-L) is prepared by making standard dilutions of purified protein derivative of tuberculin. The tuberculin test detects the presence of tuberculosis; those persons who react positively should then be vaccinated against the disease. The tuberculin test serves as a means of both early diagnosis and of evaluation of the course of tuberculosis. Only the intracutaneous Mantoux test is in wide use in the USSR.

Veterinaries use the tuberculin test to diagnose tuberculosis in animals. The tuberculin is occasionally injected subcutaneously; more commonly, it is injected intracutaneously or into the conjunctival sac. Animals that react positively are considered tuberculotic. A positive reaction is manifested by inflammatory edema after an intracutaneous injection and by purulent conjunctivitis in the eye test.


A preparation containing tuberculoproteins derived from Mycobacterium tuberculosis used in the tuberculin test to determine sensitization to tubercle bacilli.
References in periodicals archive ?
Can we improve the return rate for tuberculin skin test Readings?
The partial intradermal injection of mammalian tuberculin into sensitized tilapia did not produced visible and measurable localized skin response.
National and international guidelines have consistently recommended INH prophylaxis given for 6 months in children under 5 years of age or HIV-infected children of any age, who are exposed to a household TB contact or have a positive tuberculin skin test.
As shown in Table II, the majority of these studies examined the risks and benefits of treatment with INH in healthy individuals with a positive tuberculin skin test but no other risk factors.
A 5 mm cut-off point was adopted for a positive test result in subjects with active disease; for other persons with an increased probability of recent infection or with other clinical conditions that increase the risk for progression to active TB, > 10 mm of induration is considered positive for persons at low risk for TB, for whom tuberculin testing is not generally indicated, > 15 mm of induration is considered positive.
Comparison of T-cell-based assay with tuberculin skin test for diagnosis of mycobacterium tuberculosis infection in a school tuberculosis outbreak.
Also, patients under-going anti-TNF-[alpha] therapy who are exposed to an individual with active TB should be initiated on INH prophylaxis regardless of their tuberculin skin test results, he said.
Mantoux testing was performed with tuberculin purified protein derivative (PPD) RT 23 SSI (Statens Serum Institut; Copenhagen).
16 Morbidity and Mortality Weekly Report, said the new test can be administered in place of the 100-year-old tuberculin skin test, which involves injections on the forearm delivered through six tiny prongs and requires patients to return to their physician days later to interpret results.
The Assembly says it will provide tuberculin for testing but farmers will have arrange and pay for the tests themselves.
An atlas of sensitivity to tuberculin, PPD-B, and histoplasmin in the United States.