Ubiquitin specific protease 7 plays a key role in two important cancer pathways: it promotes the formation and function of regulatory T cells by deubiquitinating and stabilizing FOXP3; and it maintains low levels of p53, a prevalent tumor suppressor protein
, thereby allowing the tumor to grow unchecked.
Structure-function analysis of the retinoblastoma tumor suppressor protein
- is the whole a sum of its parts?
For two decades, cancer researchers have looked unsuccessfully for ways to develop compounds to restore the function of mutant p53 proteins--the most important tumor suppressor protein
that protects human cells from becoming cancerous.
But due to maximum tolerated dose ("MTD") not yet being identified and data indicating that the effect of Kevetrin on p53, a key tumor suppressor protein
, is dose dependent as expected, it has requested an amendment to the protocol to continue to evaluate administration of Kevetrin at higher doses.
The carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1), another promising tumor suppressor protein
, has been shown to upregulate SASH1.
Rubinfeld B, Albert I, Porfiri E, Munemitsu S, Polakis P -Loss of beta-catenin regulation by the APC tumor suppressor protein
correlates with loss of structure due to common somatic mutations of the gene.
Chodosh MD, PhD, chair of Cancer Biology and director of Cancer Genetics at the Abramson Family Cancer Research Institute, implicates the tumor suppressor protein
Par-4 in recurrent breast cancer.
The p53 protein history dates from the year 1979, when it was only seen as a tumor suppressor protein
The VHL tumor suppressor protein
usually forms elaborate complexes to negatively regulate cellular proteins, such as hypoxia-inducible factors.
Further studies on human cells measured the activity of the Hippo pathway while manipulating human Kibra and showed that like its fruit fly counterpart, human Kibra acts as a tumor suppressor protein
that regulates Hippo signaling.
Scientists have discovered a new role in cancer protection for an already well-known tumor suppressor protein
They found the natural compound affects multiple pathways related to cancer, such as activating the p53 tumor suppressor protein
and promoting apoptosis (programmed cell death).