two-hit model

two-hit model

[′tü ‚hit ¦mäd·əl]
(genetics)
The hypothesis that a cancer arises in an individual heterozygous for a mutant gene for a dominantly inherited form of cancer only if an additional mutation occurs in a somatic cell; for example, in the normal allele at the same locus, as in human retinoblastoma.
References in periodicals archive ?
Thus, in this two-hit model, LPS-induced inflammation accelerated [alpha]-syn accumulation, aggregation, and nitration.
2007), our two-hit model created by a moderately toxic dose of LPS (3 x [10.
A two-hit model would explain much better than a single-hit model the regulation of the vascular permeability.