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ubiquitin

   Also found in: Medical, Acronyms, Wikipedia 0.03 sec.
ubiquitin [yü′bik·wə‚tin]
(biochemistry)
A small, 76-amino-acid, highly conserved protein present in the cytoplasm and nucleus of all eukaryotes (but not eubacteria and archaea). The covalent, ATP-dependent linkage of multiple ubiquitin molecules to proteins serves as a signal for their degradation by the 26S proteasome.


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Genes involved in neuronal cell adhesion (including NRXN1, CNTN4, NLGN1, ASTN2) were enriched with copy number variation in ASD cases, compared with controls, as were genes involved in ubiquitin degradation (including UBE3A, PARK2, RFWD2, and FBXO40).
She said that, in humans, the SIAH ubiquitin ligases sit smack in the middle of the molecular pathway that leads to pancreatic cancer.
Genzyme Corporation (Cambridge, MA) has patented pDNA vectors containing the human cellular ubiquitin B (Ub) promoter.
 
 
 
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