uncouple

(redirected from uncoupler)
Also found in: Dictionary, Thesaurus, Medical, Legal, Wikipedia.

uncouple

[¦ən′kəp·əl]
(engineering)
To unscrew or disengage.
References in periodicals archive ?
Initially considered as direct inhibitor of PKC[delta], its property of being a mitochondrial uncoupler was actually responsible for inhibiting kinases.
Addition of an uncoupler leads to a decrease in the mitochondrial membrane potential, which subsequently gives rise to a maximal stimulation of the respiratory rate (18).
We conclude that Chara does produce allelopathic compounds, and we are currently testing the hypothesis that Chara secretes a water soluble chemical that inhibits photosynthesis while acting as a respiratory uncoupler.
After the pre-incubated ovaries were macerated, isolated follicles were soaked in the gap junction uncoupler for another 3 h.
Antimicrobial agent triclosan is a proton ionophore uncoupler of mitochondria in living rat and human mast cells and in primary human keratinocytes.
Furthermore, it was also reported that anacardic acids with four concentrations C15:3, C15:2, C15:1 or C15:0 showed uncoupling effects of alkyl side chains (similar to the classical uncoupler 2,4-dinitrophenol) on the ADP/O ratio, state 4 and respiratory control ratio in succinate-oxidizing rat liver mitochondria (Toyomizu et al.
When immune responses are overstimulated or essential systems compromised by metabolic uncoupler toxins or essential factor deficits, repair is deferred, tissue permeability increases, and the immune system can access and attack structural or cellular elements (see Table 4, p.
Further, the features of metabolic activation in experiments with uncouplers are often sensitive to the nature of the particular uncoupler used, its concentration, and other aspects of the experimental protocols.
Tenders are invited for Emd Pt No:9520074 Dlw Pt No 17083369 Bracket Uncoupler As Per Enclosed Drawing.
The uncoupler carbonyl cyanide m-chlorophenyl hydrazone (CCCP) was used as a control because it decreases MIMP.
found that pharmacological AMPK activation by using 5-aminoimidazole-4-carboxamide riboside (AICAR) and metformin increased mitochondria-related genes including cytochrome c and uncoupler protein 2, which is canceled in PGC-1[alpha]-deficient myotubes [82].
Because it seemed that the Cx43 antibody specifically recognized an antigen behaving like rat heart Cx43 in Western blots and acted like a gap junction uncoupler to block luminescent responses, we undertook to determine by immunohistochemistry whether Cx43-like immunoreactivity is present in the photocyte-rich endoderm.