urokinase


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Related to urokinase: streptokinase

urokinase

[‚yu̇r·ə′kī‚nās]
(biochemistry)
An enzyme, present in human urine, that catalyzes the conversion of plasminogen to plasmin.
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References in periodicals archive ?
Soluble urokinase plasminogen activator receptor in plasma is associated with incidence of CVD.
Analysis of urokinase and alteplase at varying concentrations showed that clotted samples treated with alteplase at a concentration of 0.
Our complication results are similar to those reported by Berridge et al in a review of 19 trials of intra-arterial thrombolysis using alteplase, streptokinase, and urokinase, in which minor bleeding occurred in approximately 15% of patients and major bleeding occurred in 5% (13).
Prognostic significance of the receptor for urokinase plasminogen activator in breast cancer.
No effect had been achieved with management of heparin and urokinase.
He agreed that recombinant tissue-type plasminogen activator (rt-PA), urokinase, and streptokinase are not believed to cross to an embryo or fetus in amounts sufficient to cause hemorrhage.
Clinicians used urokinase therapy alone to treat 35 limbs in 31 patients, 11 of whom were men.
9,14-24,35-37) The body of evidence addresses the use of urokinase in the treatment of IVH, which increased significantly after the innovative work of Pang et al (9,35) regarding the lysis of intraventricular blood clots with urokinase in a canine experimental model.
The androgen-insensitive prostate cells were stimulated by saposin C to express higher levels of the urokinase plasminogen activator and its receptor, two proteins known to be involved in cell invasion.
The optimal dosing for urokinase might be 250,000-500,000 U/hr for urokinase (mixed in 100 cc of normal saline).
There are also some reports which indicate that urokinase antigen in plasma is often increased in malignant diseases (Huber et al.