warfarin


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warfarin

(wôr`fərĭn), anticoagulantanticoagulant
, any of several substances that inhibit blood clot formation (see blood clotting). Some anticoagulants, such as the coumarin derivatives bishydroxycoumarin (Dicumarol) and warfarin (Coumadin) inhibit synthesis of prothrombin, a clot-forming substance, and other
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 used to treat blood clots. In large doses it causes bleeding, and in patients with genetic variations that increase sensitivity to the drug and decrease the rate at which it is metabolized standard dosages may also cause bleeding. Warfarin, mixed with bait, is used in rodent control.
References in periodicals archive ?
Internal bleeding may not be obvious," Beizer says, "so speak with your doctor if you start to feel lightheaded, winded, or more fatigued than usual while taking warfarin.
55) when compared with warfarin (at an international normalized ratio [INR] goal of 2-3).
In conclusion, this study emphasizes that genetic polymorphism must be studied for a patient having a history of mitral valve replacement and bleeding secondary to warfarin toxicity, and adjustment must be done according to the results of that study.
It has been reported that continuing warfarin therapy during pacemaker implantation could be safer than interrupting treatment.
Key Words: Anticoagulant, Bleeding, INR, Oral Surgery, warfarin, Peshawar.
Many publish studies have cited that warfarin interactions with drugs and herbs are common and harmful.
First, the warfarin dosing strategies varied in the 2 trials.
The increase in antithrombin concentration during warfarin therapy in that study (2) was based on assay methods using serum and demonstrating inhibition of human thrombin.
The study, which was completed recently and has not been published, found that dabigatran, compared with warfarin, was associated with a lower risk of ischemic stroke, intracranial hemorrhage, and death, according to the FDAs statement on the findings.
Patients being treated for bacterial upper respiratory infections with antibiotics such as metronidazole (Flagyl) and trimethoprim-sulfamethoxazole (Septra) are at increased risk since these drugs are known to interfere with Warfarin metabolism.

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