wild type

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wild type

[′wīld ‚tīp]
(genetics)
The most prevalent allele or character in the wild organism.
References in periodicals archive ?
scientists have presented data from preclinical studies involving H3B-6545, an oral, selective small molecule covalent antagonist of wild-type and mutant estrogen receptor (ER) in a poster session at the San Antonio Breast Cancer Symposium (SABCS) annual meeting, the company said.
Therefore, we designed 5 different single-target assays using primers capable of simultaneously amplifying vaccine and wild-type YFV strains.
The complete approval for Vectibix as a treatment for patients with wild-type KRAS mCRC was based on results from the Phase 3 PRIME and ASPECCT trials.
7 also reported significantly longer PFS for GBM patients with IDH1 mutation compared to wild-type IDH1.
We used a mixture of human genomic DNA (Promega) as a source of wild-type DNA and as negative control during our experiments.
The state of KRAS gene, whether wild-type (normal) or mutated (abnormal), is already known to predict the metastatic colorectal cancer patients' treatment response to anti-EGFR targeted therapy, a treatment inhibiting cell membrane growth factor receptors that are crucial in the control of key cellular transduction pathways and that are often over-expressed in various human tumors including colorectal cancers.
Growth characteristics of the reference wild-type (WT), complemented ([DELTA]tolC+) and mutant ([DELTA]tolC) strains were assessed by growth kinematics studies at 37[degrees]C.
sup][13] NKCC1 phosphorylation is decreased in the aorta of SPAK-deficient mice when compared with wild-type mice.
The approval is based on the results of a phase III study, CheckMate 066, which found a significant overall survival (OS) benefit for nivolumab, compared with chemotherapy, as a first-fine treatment of patients with BRAF wild-type advanced melanoma, according to a press release issued by Bristol-Myers Squibb (BMS) in November.
Model of acute airway inflammation induced by intranasal administration of lipopolysaccharide (LPS) was employed in both the wild-type and the MPO deficient mice.
Wild-Type KRAS is required for panitumumab efficacy in patients with metastatic colorectal cancer.