xanthoma

(redirected from xanthomas)
Also found in: Dictionary, Thesaurus, Medical.

xanthoma

[zan′thō·mə]
(medicine)
A yellowish mass of lipid-filled histocytes occurring in subcutaneous tissue, often around tendons.
References in periodicals archive ?
Tendon xanthomas are highly specific for FH in subjects with genetic high LDL cholesterol, and are an important diagnostic criterion.
All three members of the family presented extensive tendon xanthomas.
Xanthoma cells and muciphages are the most common cell constituents of foam cell infiltrates.
2) Pathologically, GCT of the tendon sheath is a highly vascular mass with an admixture of multinucleated giant cells, hemosiderin deposits, macrophages, fibroblasts and xanthoma cells: the same histologic features as PVNS.
These patients also present with eruptive xanthomas, lipemia retinalis, and pancreatitis but this disorder is usually not expressed in childhood.
45] More than 150 mutations exist in the LDL-R gene associated with FH, an autosoma1 dominant inherited disorder characterized by severe hypercholesterolernia, frequent presence of tendon xanthomas, and an elevated risk of premature CAD.
Classical are cases with tendon xanthomas in patients along LDLR gene mutation with hyperlipidemia.
Familial hypercholesterolemia can readily be identified when a plasma cholesterol concentration >7 mmol/L (>271 mg/dL) (fasting or nonfasting) is associated with xanthomas and/or a family/ personal historyofpremature CVD.
Xanthomas will be CD68 positive and negative for cytokeratin and AMACR.
Reports of xanthomatosis in birds include xanthomatosis in commercial chickens attributed to fat-related toxic hydrocarbons in feed (14); oral xanthoma in a budgerigar (Melopsittacus undulatus) (15); xanthomas overlying the carporadial-carpoulnar joint (16) and leg (17) of racing pigeons (Columba livia); a case series of xanthomas in 8 budgerigars and 1 rose-breasted cockatoo (Cacatua roseicapilla) (18); periarticular xanthomatosis in an American kestrel (Falco sparverius) (19); and xanthomatosis of the liver in an Amazon parrot.
Small, yellow-orange or red-brown plaques that "explode" over a few days or weeks and are located all over the body but concentrated on the elbows and knees are probably eruptive xanthomas associated with extremely high triglyceride levels (into the thousands).
They include acanthosis nigricans and NLD, both seen in this patient, as well as bullous diabeticorum, diabetic dermopathy, eruptive xanthomas, generalized granuloma annulare, infections (yeast or bacterial), neuropathic foot ulcers, and scleredema.