xanthoma

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Related to xanthomata: xanthelasma, malar flush

xanthoma

[zan′thō·mə]
(medicine)
A yellowish mass of lipid-filled histocytes occurring in subcutaneous tissue, often around tendons.
References in periodicals archive ?
FH is identified by family history and the finding of tendon xanthomata.
Tendon xanthomata are most commonly found in the Achilles tendon (Fig.
On physical examination, eruptive xanthomata are frequently present (Fig.
The homozygous FH phenotype produces cutaneous and tendinous xanthomata before adolescence, LDL cholesterol >14 mmol/l, very premature coronary disease, and aortic stenosis.
Diagnosis of FH was based on (a) the presence of increased plasma total and LDL-cholesterol before lipid-lowering therapy, (b) increased plasma total and LDL-cholesterol in a first-degree relative, (c) tendon xanthomata, and (d) a family history of premature CVD and/or stroke and/or sudden death.
Familial hypercholesterolaemia (FH), an autosomal dominantly inherited disorder characterised by elevated plasma low-density lipoprotein (LDL) cholesterol levels, tendon xanthomata and premature ischaemic heart disease, is amenable to treatment with modern medication.
The proband was identified based on the presence of severe hypercholesterolemia and the presence of tendon xanthomata in accordance with established diagnostic criteria (8).
FH is characterized clinically by an increase in the concentration of LDL cholesterol in blood, tendon xanthomata, and an increased risk of myocardial infarction, and is present in 5-10% of individuals who develop coronary artery disease under the age of 55 years in the UK and the US [32, 33].