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Related to xeroderma: ichthyosis


A congenital skin disease characterized by dryness and scales, especially on the extensor surfaces of the extremities.



fish skin disease, xeroderma, a skin disease characterized by sharply increased keratogenesis and retarded keratolysis.

Incidence of ichthyosis is a familial condition in half the cases and hereditary in 25 percent. It appears in early childhood (most often around age three), intensifies at puberty, and lasts throughout life. It is expressed in dryness of the skin and the accumulation of horny masses on the skin’s surface, in the form of scales or of massive horny plates that resemble fish scales. The excretion of oil and perspiration decreases sharply. The affection spreads over the entire skin surface, except at joint folds, axillae, and inguinal folds. On the face and scalp, ichthyosis appears in the form of furfuraceous desquamation. The condition of the skin improves in the summertime as a result of increased excretion of oil and sweat. Ichthyosis is treated with hot baths containing soda or table salt, followed by lubrication of the skin with emollient creams. Cod-liver oil and vitamins may be taken internally (in particular vitamin A). In the summer, prolonged sojourns in the south can be helpful (sea bathing).


References in periodicals archive ?
One female patient of age 18 years had features of xeroderma pigmentosum (who have more predilection for cutaneous malignancies) presented with basal cell carcinoma [see Fig.
Ali wants to get Jan out of Turkey and to the United States, perhaps to Sacramento, which has a population of children with the disease as well as an xeroderma pigmentosum family support group.
Prevention of skin cancer in xeroderma pigmentosum with the use of oral isotretinoin.
Xeroderma pigmentosum group F caused by a defect in a structurespecific DNA repair endonuclease.
Sequence specificity of aflatoxin Bl-induced mutations in a plasmid replicated in xeroderma pigmentosum and DNA repair proficient human cells.
17) In addition, patients with certain rare, genetic skin diseases, such as xeroderma pigmentosum (XP), are also at increased risks of developing skin cancers in sun-exposed body sites at early ages.
The variant form of human syndrome Xeroderma Pigmentosum (XP-V) is caused by mutations in DNA polymerase (hpoln).
Exclusion criteria included lesions with a diameter larger than 3 cm, penetration of malignant cells deeper than mid-dermis, pregnancy, patients younger than 30, recurrence after excision, comorbidity such as immunodeficiency, and ge-netic susceptibility for BCC such as xeroderma pigmentosum and keloid formation.
Dorey and Yolanda Nez are a married Navajo couple who bear an unjust burden: their daughter (Leanndra, 16) and her younger brother (who passed away at age 11) were both born with Xeroderma Pigmentosum, also known as XP.
Therapeutic inhibition of DNA repair in cancer cells can sensitize the cancer cells towards the chemotherapeutics or else they can function as synthetic lethal approach for treatment of cancers with DNA repair defects such as Nucleotide Excision Repair (NER) of Xeroderma pigmentosum.
Both albinism and xeroderma pigmentosum (XP) are very common in this part of East Africa.
that caters to children with xeroderma pigmentosum (XP), a rare genetic disease that causes severe sun-sensitivity disorders.