zinc finger


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Related to zinc finger: Leucine zipper

zinc finger

[¦ziŋk ¦fiŋ·gər]
(biochemistry)
A small structural domain that is organized around a zinc ion and is found in many gene-regulatory proteins.
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Only the region of DNA binding domain containing zinc finger is structured (Fig.
Downregulation of zinc finger protein 132 in prostatecancer is associated with aberrant promoter hypermethylation and poor prognosis.
The carboxyl domain of zinc finger s of the Evi-1 myeloid transforming gene binds a consensus sequence of GAAGATGAG.
Two pairs of zinc finger modules displayed MEL-1 activity at 110.
We demonstrated GA priming effect on the expression of two stress responsive genes OsZat 12-1 and OsZat 12-9 (belonging to zinc finger gene family) under saline conditions and it was observed that in case of OsZat 12-1 there was no expression in seedlings from hydroprimed seeds under salt stress, while expression was observed for GA primed plants grown under different salt conditions (Fig.
KRAB zinc finger proteins are the subject of intensive research as scientists try to sort out their many regulatory roles within the genome.
Zinc finger (ZF) motifs which are classified based on the arrangement of the zinc- binding amino acids are present in many transcription factors and have critical functions in interactions with other molecules.
Zinc finger editing is not perfect--at least, not yet--so only about 20 per cent of the modified cells actually lacked the doorway receptor gene.
The researchers used a specialized tool, a genetically engineered zinc finger (ZF) protein, which they custom-designed to latch onto a specific DNA site carrying the code for fetal hemoglobin.

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